Research: The reincarnation- A High Impact Short Communication (Ravichandra Vemuri)

Volume: 1 Issue: 1                                                                                                   April: 4

                           

Research: The reincarnation- A High Impact Short Communication

Ravichandra Vemuri

Department of  Pharmacy, Priyadarshini College of Pharmacy

The word “Research” is so reverberating and most clichéd these days. One in every hundred science students utter this word every second (not based on any survey, but by personal observation). However, the actually meaning of it is overlooked. This blog or this overview is not intended define research to you all, but this will help student know what actual research is. In retrospect, things thrived from nadir to zenith level in terms of sophistications. By inventions in past, one can say that people ventured into things and invented things without any prototypes. Now, the so-called researchers are taking the prototypes/archetypes and ameliorating them. By the above statement I would like to streamline the importance of unprecedented inventions in the past. All the inventions, discoveries in past were done practically, there were neither SOPs nor guidelines followed. I wonder how they could manage to do so.  After a lot of vacillating thoughts and my professional experience, I found this is due to sheer interest. This interest led them to found the unprecedented things, and is the prime to do research.

 Another important thing to develop as a researcher is develop a good thought process. An apple falling from a tree noticed by Isaac Newton led to the discovery of the famous Newton laws. This was possible only due the thought process. Unless, Newton gave a thought about it, there wouldn’t have been the laws of motion. This small thing influenced him to think in depth. If interest is the first step, then thought process is the second one.

 Till today, I believe “need” is the mother of all researches. Everything has its pros n cons. All the drug research for example is intended for need and human use. If not to become opulent, one should research in order to be at least helpful to few.  Graham Bell, the eminent inventor of telephone is the perfect example for the above. If one would find about the reason for invention of hearing aids which became the precursor for the discovery of the Telephone. Bell’s mother suffered hearing impairment, due to which he developed an instrument for hearing at age of 12.

To conclude, the amalgam of interest, thought process and need is research. So, I urge all to show interest, think well and serve the need of the hour.

 With due respect towards the researchers and research, this blog gives a chance and unique opportunity to all the students\ professionals to think out page and present their articles. The articles publishing is free of cost, the articles would be published after severe scrutiny of content. All copyrights reserved only to authors.

Morgellons disease: A mystic skin ailment- A High Impact Short Communication (Diana Vivian Atigari)

Volume: 1 Issue: 1                                                                                                   April: 4

 Morgellons disease: A mystic skin ailment- A High Impact Short Communication

               

                                                               Diana Vivian Atigari*

             Department of Pharmacolgy ,  Malla Reddy Institute of Pharmaceutical Sciences,                 

                          Maisammaguda , Dhulapally(Post via Hakimpet), Secunderabad ( 500014) ,AP, India.

                       

                        *Corresponding Author E-mail; diana.vivian7@gmail.com

              

Today, Morgellons stands as a very poorly understood disease. Unfortunately, the disease is usually disfiguring as well as disabling.

                                              

                 

Morgellons disease is the popular name for an unexplained skin disorder characterized by disfiguring sores and crawling sensations on and under the skin. This disease also features fibers or solid materials emerging from these sores.

Besides the sensations underneath their skin, the inflicted will suffer from persistent itchy sores and rashes all over the skin and from time to time develop multicolored (blue, black or red) fiber like protrusions within their sores and the surrounding skin.

                                                 

                        

Morgellons has drawn increasing attention since 2002. The disease is classified by biting, itching, or crawling sensations, filaments that grow from the skin, and skin lesions, as well as memory loss, joint paint, and fatigue. Adults and children are equally afflicted by the illness.

Morgellons is still not recognized by the entire medical community, but there have been about 2,000 people who believe they suffer from the disease. Some of the reports are children, who are said to be unable to do normal things such as going to school or playing sports. There is no known cure or effective treatment for Morgellons.There is no definitive understanding of how the disease is transmitted. There is no conclusive evidence showing whether it is contagious. A cure will be pursued when enough research is done to find its cause.

Volume:1 April:4 Contemporary Advances in Anti-Obesic Drugs- Short Communication

Volume: 1 Issue: 1                                                                                                   April: 4

Contemporary Advances in Anti-Obesic Drugs- Short Communication

Rohit Gundamaraju^1*

¹ Department of Pharmacolgy ,  Malla Reddy Institute of Pharmaceutical Sciences ,                  

              Maisammaguda ,Dhulapally(Post via Hakimpet) ,Secunderabad (500014)           

                                                                AP,India.

Recent advances in the understanding of energy balance control have resulted in the exploitation of a large number of new targets, some of which have yielded promising data in clinical trials for weight loss. A second major trend is derived from the hypothesis that improved weight loss efficacy over current therapy is more likely to emerge from treatments targeting multiple mechanisms of energy balance control. Many of these approaches also utilize advances in formulation technology to widen safety margins. Finally, the practicality of peptide therapies for obesity has become better validated in recent studies, and this may allow more rapid exploitation of novel targets, rather than awaiting the development of orally available small molecules. Despite the limitations of current drugs and their declining use in some jurisdiction, anti-obesity drugs still accounted for sales of nearly a half billion US dollars in the seven largest global markets during 2000. Since overall sales of anti-obesity drugs projected to at least triple by 2010, development of effective drugs has become a research priority and an area

of intense clinical interest.

The new anti-obesity drugs under clinical development include agents affecting peripheral and central mechanisms. In the first group, we can include gastrointestinal lipase inhibitor (cetilistat), amylin and leptin analogs, thermogenic agents, that is, selective β3 receptor agonists, agonist of the glucagon-like peptide 1 (GLP-1) (Exendin-4, Liraglutide). In the second group, we can consider agents that modulate the central activity of neuropeptides influencing food intake and including antiepilepsy drugs (topiramate, zonisamide), noradrenaline and dopamine reuptake inhibitors (bupropion, tesofensine) that were studied in monotherapy or in combination (bupropion-naltrexone and phenterminetopiramate); human ciliary neurotrophic factor (axokine), human GH fragment (AOD9604, AOD9401), melanocortin receptor selective agonists (MC4R), melanin-concentrating hormone antagonists, serotoninergic drugs including selective 5-HT2C receptor agonists (lorcaserin), components of neuropeptide Y (NPY) signaling pathway (CAMKK2).

Volume 1: April 4th: Editorial Post

Volume 1   Editorial issue:

Dear young success seekers,

This research journal blog provides you with all the freedom to post your views and elements in the field of pharmacy and medicine. This thought rooted in my mind when I was thinking about the “future India”. The major aspect which is lacking in our country is “encouragement” for research and wide thinking abilities. Understanding a single mechanism about any facet in the human body will surely unravel many things. There are many mysteries yet to be untwined which will answer many questions. Many illnesses are throwing challenges to researchers. Answer for every issue comes from a single word “thinking” and understanding the core.